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Yotsuba&! (よつばと!, Yotsuba to!?) is an ongoing Japanese comedy manga series by Kiyohiko Azuma, the creator of Azumanga Daioh. It is published in Japan by ASCII Media Works, formerly MediaWorks, in the monthly magazine Dengeki Daioh and collected in ten tankōbon volumes as of November 2010. It depicts the everyday adventures of a young girl named Yotsuba as she learns about the world around her, guided by her father, the neighbors, and their friends. Several characters in Yotsuba&! were previously featured in a one-shot manga called "Try! Try! Try!" The phrase Yotsuba to means "Yotsuba and," a fact reflected in the chapter titles, most of which take the form "Yotsuba and something."

The manga was licensed for English-language distribution by ADV Manga, which released five volumes between 2005 and 2007. Volume six was supposed to have been released in February 2008, but was delayed indefinitely in order to focus on ADV's core business of anime. At New York Comic Con 2009, Yen Press announced that it had acquired the North American license for the series; it reprinted the first five volumes with new translations along with volume six in September 2009, and is continuing with later volumes.